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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG009461

Entrez Gene ID

50943

Official Gene Symbol

FOXP3

Synonyms

AIID|DIETER|IPEX|MGC141961|MGC141963|PIDX|XPID

Gene name

forkhead box P3

Gene Type

protein-coding

Chromosome

0

Genomics Location

Xp11.23

Known cancer genes

Yes

Protein products

Forkhead box protein P3

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Primary biliary cirrhosis

Autoimmune hepatitis

Database cross reference

HGNC:6106
MIM:300292
Ensembl:ENSG00000049768
HPRD:02242
RefSeq Genomic nucleotide accession:AC_000066
RefSeq Genomic nucleotide gi:89161217

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001782

B cell homeostasis

GO:0001816

cytokine production

GO:0002053

positive regulation of mesenchymal cell proliferation

GO:0002262

myeloid cell homeostasis

GO:0002456

T cell mediated immunity

GO:0002513

tolerance induction to self antigen

GO:0002637

regulation of immunoglobulin production

GO:0002669

positive regulation of T cell anergy

GO:0002677

negative regulation of chronic inflammatory response

GO:0002725

negative regulation of T cell cytokine production

GO:0002851

positive regulation of peripheral T cell tolerance induction

GO:0003682

chromatin binding

GO:0003690

double-stranded DNA binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003705

sequence-specific enhancer binding RNA polymerase II transcription factor activity

GO:0003714

transcription corepressor activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005667

transcription factor complex

GO:0005737

cytoplasm

GO:0006338

chromatin remodeling

GO:0006351

transcription, DNA-dependent

GO:0006355

regulation of transcription, DNA-dependent

GO:0007389

pattern specification process

GO:0007519

skeletal muscle tissue development

GO:0008270

zinc ion binding

GO:0008285

negative regulation of cell proliferation

GO:0008301

DNA bending activity

GO:0009615

response to virus

GO:0009790

embryo development

GO:0009791

post-embryonic development

GO:0021549

cerebellum development

GO:0021757

caudate nucleus development

GO:0021758

putamen development

GO:0021987

cerebral cortex development

GO:0031064

negative regulation of histone deacetylation

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO:0032689

negative regulation of interferon-gamma production

GO:0032693

negative regulation of interleukin-10 production

GO:0032703

negative regulation of interleukin-2 production

GO:0032713

negative regulation of interleukin-4 production

GO:0032714

negative regulation of interleukin-5 production

GO:0032715

negative regulation of interleukin-6 production

GO:0032720

negative regulation of tumor necrosis factor production

GO:0032792

negative regulation of CREB transcription factor activity

GO:0032831

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

GO:0032914

positive regulation of transforming growth factor-beta1 production

GO:0033092

positive regulation of immature T cell proliferation in thymus

GO:0035035

histone acetyltransferase binding

GO:0035066

positive regulation of histone acetylation

GO:0035067

negative regulation of histone acetylation

GO:0040007

growth

GO:0042036

negative regulation of cytokine biosynthetic process

GO:0042110

T cell activation

GO:0042130

negative regulation of T cell proliferation

GO:0042297

vocal learning

GO:0042803

protein homodimerization activity

GO:0042826

histone deacetylase binding

GO:0043010

camera-type eye development

GO:0043029

T cell homeostasis

GO:0043234

protein complex

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

GO:0043565

sequence-specific DNA binding

GO:0045077

negative regulation of interferon-gamma biosynthetic process

GO:0045085

negative regulation of interleukin-2 biosynthetic process

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046007

negative regulation of activated T cell proliferation

GO:0046872

metal ion binding

GO:0046982

protein heterodimerization activity

GO:0048286

lung alveolus development

GO:0048294

negative regulation of isotype switching to IgE isotypes

GO:0048302

regulation of isotype switching to IgG isotypes

GO:0048745

smooth muscle tissue development

GO:0050710

negative regulation of cytokine secretion

GO:0050777

negative regulation of immune response

GO:0050852

T cell receptor signaling pathway

GO:0051059

NF-kappaB binding

GO:0051525

NFAT protein binding

GO:0060013

righting reflex

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis