HuLG009685

Entrez Gene ID

51284

Official Gene Symbol

TLR7

Gene name

toll-like receptor 7

Gene Type

protein-coding

Chromosome

0

Genomics Location

Xp22.3

Known cancer genes

Yes

Protein products

TLR7

TLR7

TLR7

Toll-like receptor 7

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Database cross reference

HGNC:15631
MIM:300365
Ensembl:ENSG00000196664
HPRD:02295
RefSeq Genomic nucleotide accession:AC_000066
RefSeq Genomic nucleotide gi:89161217

GO annotation

GO:0002282

microglial cell activation involved in immune response

GO:0003725

double-stranded RNA binding

GO:0003727

single-stranded RNA binding

GO:0004888

transmembrane receptor activity

GO:0005737

cytoplasm

GO:0005764

lysosome

GO:0005768

endosome

GO:0005783

endoplasmic reticulum

GO:0005789

endoplasmic reticulum membrane

GO:0005886

plasma membrane

GO:0007165

signal transduction

GO:0007252

I-kappaB phosphorylation

GO:0008144

drug binding

GO:0010008

endosome membrane

GO:0016021

integral to membrane

GO:0031410

cytoplasmic vesicle

GO:0032009

early phagosome

GO:0032722

positive regulation of chemokine production

GO:0032755

positive regulation of interleukin-6 production

GO:0032757

positive regulation of interleukin-8 production

GO:0034154

toll-like receptor 7 signaling pathway

GO:0035197

siRNA binding

GO:0042221

response to chemical stimulus

GO:0042346

positive regulation of NF-kappaB import into nucleus

GO:0045078

positive regulation of interferon-gamma biosynthetic process

GO:0045087

innate immune response

GO:0045356

positive regulation of interferon-alpha biosynthetic process

GO:0045359

positive regulation of interferon-beta biosynthetic process

GO:0045416

positive regulation of interleukin-8 biosynthetic process

GO:0050729

positive regulation of inflammatory response

GO:0051607

defense response to virus

GO:0052033

pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity

GO:0071260

cellular response to mechanical stimulus