Gene basic information
| LiverAtlas Gene ID |
HuLG011397 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SMURF1 |
|
Synonyms |
KIAA1625 |
|
Gene name |
SMAD specific E3 ubiquitin protein ligase 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
7 |
|
Genomics Location |
7q22.1 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Database cross reference |
HGNC:16807
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000209 |
protein polyubiquitination |
|
GO:0004842 |
ubiquitin-protein ligase activity |
|
GO:0005515 |
protein binding |
|
GO:0005622 |
intracellular |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006464 |
protein modification process |
|
GO:0006611 |
protein export from nucleus |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0007398 |
ectoderm development |
|
GO:0016567 |
protein ubiquitination |
|
GO:0016874 |
ligase activity |
|
GO:0016881 |
acid-amino acid ligase activity |
|
GO:0030154 |
cell differentiation |
|
GO:0030279 |
negative regulation of ossification |
|
GO:0030509 |
BMP signaling pathway |
|
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0030514 |
negative regulation of BMP signaling pathway |
|
GO:0030579 |
ubiquitin-dependent SMAD protein catabolic process |
|
GO:0031398 |
positive regulation of protein ubiquitination |
|
GO:0032801 |
receptor catabolic process |
|
GO:0034394 |
protein localization at cell surface |
|
GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
|
GO:0043161 |
proteasomal ubiquitin-dependent protein catabolic process |
|
GO:0048185 |
activin binding |
|
GO:0070411 |
I-SMAD binding |
|
GO:0070412 |
R-SMAD binding |
