Gene basic information
| LiverAtlas Gene ID |
HuLG012092 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SMURF2 |
|
Synonyms |
DKFZp686F0270|MGC138150 |
|
Gene name |
SMAD specific E3 ubiquitin protein ligase 2 |
|
Gene Type |
protein-coding |
|
Chromosome |
17 |
|
Genomics Location |
17q22-q23 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:16809
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000151 |
ubiquitin ligase complex |
|
GO:0004842 |
ubiquitin-protein ligase activity |
|
GO:0005515 |
protein binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006464 |
protein modification process |
|
GO:0006511 |
ubiquitin-dependent protein catabolic process |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0016567 |
protein ubiquitination |
|
GO:0016874 |
ligase activity |
|
GO:0016881 |
acid-amino acid ligase activity |
|
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0030509 |
BMP signaling pathway |
|
GO:0030579 |
ubiquitin-dependent SMAD protein catabolic process |
|
GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
|
GO:0042802 |
identical protein binding |
|
GO:0045121 |
membrane raft |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0046332 |
SMAD binding |
