HuLG014377

Entrez Gene ID

114548

Official Gene Symbol

NLRP3

Synonyms

AGTAVPRL|AII|AII/AVP|AVP|C1orf7|CIAS1|CLR1.1|FCAS|FCU|FLJ95925|MWS|NALP3|PYPAF1

Gene name

NLR family, pyrin domain containing 3

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q44

Known cancer genes

Yes

Protein products

cDNA, FLJ95925, highly similar to Homo sapiens cold autoinflammatory syndrome 1 (CIAS1), mRNA

NLRP3 protein

NACHT, LRR and PYD domains-containing protein 3

AII/AVP receptor-like

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Database cross reference

HGNC:16400
MIM:606416
Ensembl:ENSG00000162711
HPRD:05915
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

GO annotation

GO:0000166

nucleotide binding

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0005737

cytoplasm

GO:0006917

induction of apoptosis

GO:0006919

activation of caspase activity

GO:0006952

defense response

GO:0006954

inflammatory response

GO:0007165

signal transduction

GO:0009595

detection of biotic stimulus

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO:0032621

interleukin-18 production

GO:0042347

negative regulation of NF-kappaB import into nucleus

GO:0042834

peptidoglycan binding

GO:0043280

positive regulation of caspase activity

GO:0050701

interleukin-1 secretion

GO:0050718

positive regulation of interleukin-1 beta secretion

GO:0051259

protein oligomerization

GO:0051607

defense response to virus