Gene basic information
| LiverAtlas Gene ID |
HuLG018789 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
CCR2 |
|
Synonyms |
CCNCKRN2|CCR2A|CCR2B|CD192|CKR2|CKR2A|CKR2B|CMKBR2|FLJ78302|MCPN1NR|MGC103828|MGC111760|MGC168006 |
|
Gene name |
chemokine (C-C motif) receptor 2 |
|
Gene Type |
protein-coding |
|
Chromosome |
3 |
|
Genomics Location |
3p21.31 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis B infection |
|
Database cross reference |
HGNC:1603
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001974 |
blood vessel remodeling |
|
GO:0002407 |
dendritic cell chemotaxis |
|
GO:0002827 |
positive regulation of T-helper 1 type immune response |
|
GO:0002829 |
negative regulation of type 2 immune response |
|
GO:0004872 |
receptor activity |
|
GO:0004930 |
G-protein coupled receptor activity |
|
GO:0004950 |
chemokine receptor activity |
|
GO:0005625 |
soluble fraction |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0005887 |
integral to plasma membrane |
|
GO:0006874 |
cellular calcium ion homeostasis |
|
GO:0006935 |
chemotaxis |
|
GO:0006954 |
inflammatory response |
|
GO:0006955 |
immune response |
|
GO:0006968 |
cellular defense response |
|
GO:0007194 |
negative regulation of adenylate cyclase activity |
|
GO:0007204 |
elevation of cytosolic calcium ion concentration |
|
GO:0007259 |
JAK-STAT cascade |
|
GO:0009611 |
response to wounding |
|
GO:0010574 |
regulation of vascular endothelial growth factor production |
|
GO:0010820 |
positive regulation of T cell chemotaxis |
|
GO:0016021 |
integral to membrane |
|
GO:0016493 |
C-C chemokine receptor activity |
|
GO:0016525 |
negative regulation of angiogenesis |
|
GO:0019221 |
cytokine-mediated signaling pathway |
|
GO:0019725 |
cellular homeostasis |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030425 |
dendrite |
|
GO:0031727 |
CCR2 chemokine receptor binding |
|
GO:0032729 |
positive regulation of interferon-gamma production |
|
GO:0032743 |
positive regulation of interleukin-2 production |
|
GO:0035696 |
monocyte extravasation |
|
GO:0035705 |
T-helper 17 cell chemotaxis |
|
GO:0042535 |
positive regulation of tumor necrosis factor biosynthetic process |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043025 |
neuronal cell body |
|
GO:0043204 |
perikaryon |
|
GO:0043310 |
negative regulation of eosinophil degranulation |
|
GO:0043615 |
astrocyte cell migration |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
|
GO:0048471 |
perinuclear region of cytoplasm |
|
GO:0050729 |
positive regulation of inflammatory response |
|
GO:0050870 |
positive regulation of T cell activation |
|
GO:0070098 |
chemokine-mediated signaling pathway |
|
GO:0090026 |
positive regulation of monocyte chemotaxis |
|
GO:0090265 |
positive regulation of immune complex clearance by monocytes and macrophages |
|
GO:2000409 |
positive regulation of T cell extravasation |
