Gene basic information
| LiverAtlas Gene ID |
HuLG019759 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
NOD2 |
|
Synonyms |
ACUG|BLAU|CARD15|CD|CLR16.3|IBD1|NLRC2|NOD2B|PSORAS1 |
|
Gene name |
nucleotide-binding oligomerization domain containing 2 |
|
Gene Type |
protein-coding |
|
Chromosome |
16 |
|
Genomics Location |
16q21 |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:5331
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000166 |
nucleotide binding |
|
GO:0000187 |
activation of MAPK activity |
|
GO:0002224 |
toll-like receptor signaling pathway |
|
GO:0002227 |
innate immune response in mucosa |
|
GO:0002253 |
activation of immune response |
|
GO:0002367 |
cytokine production involved in immune response |
|
GO:0002381 |
immunoglobulin production involved in immunoglobulin mediated immune response |
|
GO:0002606 |
positive regulation of dendritic cell antigen processing and presentation |
|
GO:0002710 |
negative regulation of T cell mediated immunity |
|
GO:0002755 |
MyD88-dependent toll-like receptor signaling pathway |
|
GO:0002756 |
MyD88-independent toll-like receptor signaling pathway |
|
GO:0002830 |
positive regulation of type 2 immune response |
|
GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
|
GO:0002925 |
positive regulation of humoral immune response mediated by circulating immunoglobulin |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005622 |
intracellular |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006952 |
defense response |
|
GO:0006965 |
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria |
|
GO:0007254 |
JNK cascade |
|
GO:0008063 |
Toll signaling pathway |
|
GO:0008180 |
signalosome |
|
GO:0009595 |
detection of biotic stimulus |
|
GO:0009986 |
cell surface |
|
GO:0016045 |
detection of bacterium |
|
GO:0019899 |
enzyme binding |
|
GO:0019901 |
protein kinase binding |
|
GO:0031982 |
vesicle |
|
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
|
GO:0032495 |
response to muramyl dipeptide |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0032498 |
detection of muramyl dipeptide |
|
GO:0032500 |
muramyl dipeptide binding |
|
GO:0032689 |
negative regulation of interferon-gamma production |
|
GO:0032695 |
negative regulation of interleukin-12 production |
|
GO:0032701 |
negative regulation of interleukin-18 production |
|
GO:0032703 |
negative regulation of interleukin-2 production |
|
GO:0032720 |
negative regulation of tumor necrosis factor production |
|
GO:0032731 |
positive regulation of interleukin-1 beta production |
|
GO:0032733 |
positive regulation of interleukin-10 production |
|
GO:0032735 |
positive regulation of interleukin-12 production |
|
GO:0032740 |
positive regulation of interleukin-17 production |
|
GO:0032755 |
positive regulation of interleukin-6 production |
|
GO:0032760 |
positive regulation of tumor necrosis factor production |
|
GO:0032874 |
positive regulation of stress-activated MAPK cascade |
|
GO:0034130 |
toll-like receptor 1 signaling pathway |
|
GO:0034134 |
toll-like receptor 2 signaling pathway |
|
GO:0034136 |
negative regulation of toll-like receptor 2 signaling pathway |
|
GO:0034138 |
toll-like receptor 3 signaling pathway |
|
GO:0034142 |
toll-like receptor 4 signaling pathway |
|
GO:0035419 |
activation of MAPK activity involved in innate immune response |
|
GO:0035556 |
intracellular signal transduction |
|
GO:0042742 |
defense response to bacterium |
|
GO:0042834 |
peptidoglycan binding |
|
GO:0042981 |
regulation of apoptosis |
|
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
|
GO:0043330 |
response to exogenous dsRNA |
|
GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
|
GO:0044130 |
negative regulation of growth of symbiont in host |
|
GO:0045087 |
innate immune response |
|
GO:0045089 |
positive regulation of innate immune response |
|
GO:0045747 |
positive regulation of Notch signaling pathway |
|
GO:0046330 |
positive regulation of JNK cascade |
|
GO:0046645 |
positive regulation of gamma-delta T cell activation |
|
GO:0050679 |
positive regulation of epithelial cell proliferation |
|
GO:0050700 |
CARD domain binding |
|
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
|
GO:0050727 |
regulation of inflammatory response |
|
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
|
GO:0050766 |
positive regulation of phagocytosis |
|
GO:0050830 |
defense response to Gram-positive bacterium |
|
GO:0050871 |
positive regulation of B cell activation |
|
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
|
GO:0051259 |
protein oligomerization |
|
GO:0051353 |
positive regulation of oxidoreductase activity |
|
GO:0051403 |
stress-activated MAPK cascade |
|
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
|
GO:0060585 |
positive regulation of prostaglandin-endoperoxide synthase activity |
|
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
|
GO:0070431 |
nucleotide-binding oligomerization domain containing 2 signaling pathway |
|
GO:0071224 |
cellular response to peptidoglycan |
|
GO:0071608 |
macrophage inflammatory protein-1 alpha production |
|
GO:0090022 |
regulation of neutrophil chemotaxis |
|
GO:2000110 |
negative regulation of macrophage apoptosis |
|
GO:2000363 |
positive regulation of prostaglandin-E synthase activity |
