HuLG019762

Entrez Gene ID

1991

Official Gene Symbol

ELANE

Synonyms

ELA2|GE|HLE|HNE|NE|PMN-E|SCN1

Gene name

elastase, neutrophil expressed

Gene Type

protein-coding

Chromosome

19

Genomics Location

19p13.3

Protein products

Neutrophil elastase

Related liver disease name

Liver fibrosis and liver cirrhosis

Database cross reference

HGNC:3309
MIM:130130
Ensembl:ENSG00000197561
HPRD:00554
RefSeq Genomic nucleotide accession:AC_000062
RefSeq Genomic nucleotide gi:89161197
http://www.ncbi.nlm.nih.gov/nuccore/AC_000151?report=genbank

GO annotation

GO:0001878

response to yeast

GO:0002438

acute inflammatory response to antigenic stimulus

GO:0004175

endopeptidase activity

GO:0004252

serine-type endopeptidase activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005737

cytoplasm

GO:0006508

proteolysis

GO:0006874

cellular calcium ion homeostasis

GO:0006909

phagocytosis

GO:0008201

heparin binding

GO:0008233

peptidase activity

GO:0009411

response to UV

GO:0009986

cell surface

GO:0019955

cytokine binding

GO:0030141

stored secretory granule

GO:0030163

protein catabolic process

GO:0032496

response to lipopolysaccharide

GO:0043406

positive regulation of MAP kinase activity

GO:0044130

negative regulation of growth of symbiont in host

GO:0045079

negative regulation of chemokine biosynthetic process

GO:0045415

negative regulation of interleukin-8 biosynthetic process

GO:0045416

positive regulation of interleukin-8 biosynthetic process

GO:0048661

positive regulation of smooth muscle cell proliferation

GO:0050728

negative regulation of inflammatory response

GO:0050778

positive regulation of immune response

GO:0050900

leukocyte migration

GO:0050922

negative regulation of chemotaxis

GO:0051635

bacterial cell surface binding

GO:0070947

neutrophil mediated killing of fungus