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Protein basic information

LiverAtlas Protein ID

HuLPr00010

Uniprot ID

1A11_HUMAN

Uniprot Acc

P13746;O19605;O19606;Q29747;Q29835;Q9BCN0;Q9MYI5;Q9TQE9;Q9TQP6;Q9TQP7;

Protein name

HLA class I histocompatibility antigen, A-11 alpha chain

Comment

FUNCTION:Involved in the presentation of foreign antigens to the immune system.||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13746-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=P13746-2; Sequence=VSP 008099; Note=Only produced by allele A*1103;||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of A-11 are known:A*11:01 (A- 11E), A*11:02 (A-11K), A*11:03, A*11:04, A*11:05 and A*11:07. The sequence shown is that of A*11:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class I, A

Protein sequence

MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFYTSVSRPG RGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQE GPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHT IQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSW TAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYL ENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPA EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP SGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIA GLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDS AQGSDVSLTACKV

Database cross reference

RefSeq Protein accession:NP_002107
RefSeq Protein gi:24797067

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;NAS:UniProtKB. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB.

GO-P

GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;NAS:UniProtKB. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.