Protein basic information
| LiverAtlas Protein ID |
HuLPr00013 |
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Uniprot ID |
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Uniprot Acc |
P30447;Q9TQF1;Q9TQF8;Q9TQG5;Q9TQM6; |
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Protein name |
HLA class I histocompatibility antigen, A-23 alpha chain |
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Comment |
FUNCTION:Involved in the presentation of foreign antigens to the immune system.||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of A-23 are known:A*23:01, A*23:02, A*23:03, A*23:04 and A*23:05. The sequence shown is that of A*23:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain. |
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Subcellular localization |
Membrane;Single-pass type I membrane protein. |
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Gene name |
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Protein sequence
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MAVMAPRTLVLLLSGALALTQTWAGSHSMRYFSTSVSRPG RGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQE GPEYWDEETGKVKAHSQTDRENLRIALRYYNQSEAGSHT LQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSW TAADMAAQITQRKWEAARVAEQLRAYLEGTCVDGLRRYL ENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPA EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP SGEEQRYTCHVQHEGLPKPLTLRWEPSSQPTVHIVGIIA GLVLLGAVITGAVVAAVMWRRNSSDRKGGSYSQAASSDS AQGSDVSLTACKV |
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Database cross reference |
RefSeq Protein accession:NP_002107
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW. |
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GO-P |
GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;IEA:InterPro. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr00013 |
PHOSPHORYLATION |
356 |
S |
Phospho-ELM |
HTP |
yes |
 
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|
|
HuLPr00013 |
PHOSPHORYLATION |
359 |
S |
Phospho-ELM |
HTP |
yes |
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