HuLPr00014

Uniprot ID

1A30_HUMAN

Uniprot Acc

P16188;O19598;O62921;P30452;Q9UIP7;

Protein name

HLA class I histocompatibility antigen, A-30 alpha chain

Comment

FUNCTION:Involved in the presentation of foreign antigens to the immune system.||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||INTERACTION:P30450:HLA-A; NbExp=1; IntAct=EBI-1044129, EBI-1042870; P30457:HLA-A; NbExp=1; IntAct=EBI-1044129, EBI-1049899;||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of A-30 are known:A*30:01 (A30.3), A*30:02, A*30:03, A*30:04 (A30W7), A*30:06, A*30:07 and A*30:08. The sequence shown is that of A*30:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class I, A

Protein sequence

MAVMAPRTLLLLLSGALALTHTWAGSHSMRYFSTSVSRPG SGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQE RPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHT IQIMYGCDVGSDGRFLRGYEQHAYDGKDYIALNEDLRSW TAADMAAQITQRKWEAARWAEQLRAYLEGTCVEWLRRYL ENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPA EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP SGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIA GLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDS AQGSDVSLTACKV

Database cross reference

RefSeq Protein accession:NP_002107
RefSeq Protein gi:24797067

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005887;C:integral to plasma membrane;NAS:UniProtKB. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB. GO:0005515;F:protein binding;IPI:IntAct.

GO-P

GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;NAS:UniProtKB. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.