HuLPr00015

Uniprot ID

1A33_HUMAN

Uniprot Acc

P16190;O02939;O02954;

Protein name

HLA class I histocompatibility antigen, A-33 alpha chain

Comment

FUNCTION:Involved in the presentation of foreign antigens to the immune system.||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of A-33 are known:A*33:01 (Aw-33.1), A*3302 and A*33:03. The sequence shown is that of A*33:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class I, A

Protein sequence

MAVMAPRTLLLLLLGALALTQTWAGSHSMRYFTTSVSRPG RGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQE GPEYWDRNTRNVKAHSQIDRVDLGTLRGYYNQSEAGSHT IQMMYGCDVGSDGRFLRGYQQDAYDGKDYIALNEDLRSW TAADMAAQITQRKWEAARVAEQLRAYLEGTCVEWLRRHL ENGKETLQRTDPPKTHMTHHAVSDHEATLRCWALSFYPA EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWASVVVP SGQEQRYTCHVQHEGLPKPLTLRWEPSSQPTIPIVGIIA GLVLFGAVFAGAVVAAVRWRRKSSDRKGGSYSQAASSDS AQGSDMSLTACKV

Database cross reference

RefSeq Protein accession:NP_002107
RefSeq Protein gi:24797067

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW.

GO-P

GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;IEA:InterPro. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.