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Protein basic information

LiverAtlas Protein ID

HuLPr00016

Uniprot ID

1A36_HUMAN

Uniprot Acc

P30455;Q9MY89;

Protein name

HLA class I histocompatibility antigen, A-36 alpha chain

Comment

FUNCTION:Involved in the presentation of foreign antigens to the immune system.||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||INTERACTION:P30457:HLA-A; NbExp=1; IntAct=EBI-1050524, EBI-1049899;||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of A-36 are known:A*36:01 and A*36:02. The sequence shown is that of A*36:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class I, A

Protein sequence

MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPG RGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQE GPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHT IQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSW TAADMAAQITKRKWEAVHAAEQRRVYLEGTCVEWLRRYL ENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPA EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP SGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIA GLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDS AQGSDVSLTACKV

Database cross reference

RefSeq Protein accession:NP_002107
RefSeq Protein gi:24797067

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;NAS:UniProtKB. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB. GO:0005515;F:protein binding;IPI:IntAct.

GO-P

GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;NAS:UniProtKB. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.