HuLPr00052

Uniprot ID

2B11_HUMAN

Uniprot Acc

P04229;A4F5N0;A8K098;O62869;P13758;Q06662;Q30116;Q30117;Q5Y7E9;Q7M2H4;Q95461;Q9BCL7;Q9GIK5;Q9MXZ0;Q9MXZ5;Q9TQ91;

Protein name

HLA class II histocompatibility antigen, DRB1-1 beta chain

Comment

FUNCTION:Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC clas

Subcellular localization

Cell membrane;Single-pass type I membrane protein.Endoplasmic reticulum membrane;Single-pass type I membrane protein.Golgi apparatus, trans-Golgi network membrane;Single-pass type I membrane protein.Endosome membrane;Single- pass type I membrane protein.Lysosome membrane;Single-pass type I membrane protein.Late endosome membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class II, DR beta 1

Protein sequence

MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQL KFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAV TELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESF TVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIE VRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRS GEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGF VLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Database cross reference

RefSeq Protein accession:NP_002115
RefSeq Protein gi:155030211

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031902;C:late endosome membrane;IDA:UniProtKB. GO:0005765;C:lysosomal membran

GO-P

GO:0002504;P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;IEA:UniProtKB-KW. GO:0060333;P:interferon-gamma-mediated signaling pathway;TAS:Reactome. GO:0031295;P:T cell costimulation;TAS:Reactome. GO:0050852;P:

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr00052

UBIQUITINATION

254

K

PhosphoSitePlus

6140802

LTP

N

HuLPr00052

PHOSPHORYLATION

112

Y

PhosphoSitePlus

7387600

LTP

N

HuLPr00052

PHOSPHORYLATION

107

Y

PhosphoSitePlus

7387601

LTP

N

CXCR4-mediated_signaling_events

IL12-mediated_signaling_events

IL12_signaling_mediated_by_STAT4

TCR_signaling_in_naïve_CD4+_T_cells