HuLPr00054

Uniprot ID

2B18_HUMAN

Uniprot Acc

Q30134;O19718;O19788;Q29968;Q30108;Q30115;Q9BCP0;Q9BCP1;Q9BCP2;Q9BD33;Q9TQ37;Q9UIM9;

Protein name

HLA class II histocompatibility antigen, DRB1-8 beta chain

Comment

FUNCTION:Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC clas

Subcellular localization

Cell membrane;Single-pass type I membrane protein.Endoplasmic reticulum membrane;Single-pass type I membrane protein.Golgi apparatus, trans-Golgi network membrane;Single-pass type I membrane protein.Endosome membrane;Single- pass type I membrane protein.Lysosome membrane;Single-pass type I membrane protein.Late endosome membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class II, DR beta 1

Protein sequence

MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYS TGECYFFNGTERVRFLDRYFYNQEEYVRFDSDVGEYRAV TELGRPSAEYWNSQKDFLEDRRALVDTYCRHNYGVGESF TVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIE VRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRS GEVYTCQVEHPSVTSPLTVEWSARSESAQSKMLSGVGGF VLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Database cross reference

RefSeq Protein accession:NP_002115
RefSeq Protein gi:155030211

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031902;C:late endosome membrane;IDA:UniProtKB. GO:0005765;C:lysosomal membran

GO-P

GO:0002504;P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;IEA:UniProtKB-KW. GO:0006955;P:immune response;IEA:InterPro.