Protein basic information
| LiverAtlas Protein ID |
HuLPr00071 |
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Uniprot ID |
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Uniprot Acc |
P08195;Q13543; |
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Protein name |
4F2 cell-surface antigen heavy chain |
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Comment |
FUNCTION:Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D, |
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Subcellular localization |
Apical cell membrane;Single-pass type II membrane protein.Melanosome. |
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Gene name |
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 |
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Related liver disease name |
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Protein sequence
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MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELG SHCVAQTGLELLASGDPLPSASQNAEMIETGSDCVTQAG LQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNEL EPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAA AAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGM LAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQG HGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQ TDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYR GENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIEN LKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSL LESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRW CSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYG DEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMT VKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG PGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPAS ASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA |
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Database cross reference |
RefSeq Protein accession:NP_001012680
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016324;C:apical plasma membrane;IEA:UniProtKB-SubCell. GO:0009986;C:cell surface;IDA:UniProtKB. GO:0016021;C:integral to membrane;NAS:UniProtKB. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005432;F:calcium:sodium antiporter activity;TAS:UniProtKB. GO:0003824;F:catalytic activity;IEA:InterPro. GO:0043169;F:cation binding;IEA:InterPro. GO:0015175;F:neutral amino acid transmembrane transporter activity;ISS:UniProtKB. GO:0005515;F:protei |
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GO-P |
GO:0007596;P:blood coagulation;TAS:Reactome. GO:0005975;P:carbohydrate metabolic process;IEA:InterPro. GO:0016049;P:cell growth;NAS:UniProtKB. GO:0034641;P:cellular nitrogen compound metabolic process;TAS:Reactome. GO:0060356;P:leucine import;ISS:UniPr |