HuLPr00079

Uniprot ID

5HT3A_HUMAN

Uniprot Acc

P46098;O60854;Q99918;Q9BSZ9;

Protein name

5-hydroxytryptamine receptor 3A

Comment

FUNCTION:This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.||SUBUNIT:Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex are functional but exhibit low conductance, decreased agonist and antagonist affinity with modified voltage dependence. Interacts with RIC3.||SUBCELLULAR LOCATION:Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=5-HT3R-AS; IsoId=P46098-1; Sequence=Displayed; Name=2; Synonyms=5-HT3R-AL; IsoId=P46098-2; Sequence=VSP 000078;||TISSUE SPEC

Subcellular localization

Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane protein.Cell membrane;Multi-pass membrane protein.

Gene name

5-hydroxytryptamine (serotonin) receptor 3A

Protein sequence

MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDY LLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQV LTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVP DILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTAC SLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKV KSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFY VVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERV SFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCM ALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIA WLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGP QDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLE KRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA

Database cross reference

RefSeq Protein accession:NP_000860
RefSeq Protein gi:253735700

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0045211;C:postsynaptic membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0051378;F:serotonin binding;IDA:MGI. GO:0004993;F:serotonin receptor activity;NAS:UniProtKB. GO:0005232;F:serotonin-activated cation-selective channel activity;TAS:ProtInc.

GO-P

GO:0007586;P:digestion;TAS:ProtInc. GO:0007268;P:synaptic transmission;TAS:ProtInc.

IL2