Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr00080

Uniprot ID

5HT3C_HUMAN

Uniprot Acc

Q8WXA8;A2RRR5;

Protein name

5-hydroxytryptamine receptor 3C

Comment

FUNCTION:This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.||SUBUNIT:Forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.||TISSUE SPECIFICITY:Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.||SIMILARITY:Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

5-hydroxytryptamine (serotonin) receptor 3, family member C

Protein sequence

MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGV DPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVD AQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAE NLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMR VTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDK EVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYD QIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAE SENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFA LCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLL HCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGK KLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLY LLFMASSILTVIVLWNT

Database cross reference

RefSeq Protein accession:NP_570126
RefSeq Protein gi:47519867

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;TAS:Reactome. GO:0045211;C:postsynaptic membrane;IEA:InterPro.

GO-F

GO:0005230;F:extracellular ligand-gated ion channel activity;IEA:InterPro. GO:0004872;F:receptor activity;IEA:UniProtKB-KW.