HuLPr00081

Uniprot ID

5HT3D_HUMAN

Uniprot Acc

Q70Z44;C9J2I6;Q495N5;Q495N6;Q7Z6B3;

Protein name

5-hydroxytryptamine receptor 3D

Comment

FUNCTION:This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.||SUBUNIT:Forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q70Z44-1; Sequence=Displayed; Name=2; IsoId=Q70Z44-2; Sequence=VSP 029798, VSP 029799, VSP 029801; Name=3; IsoId=Q70Z44-3; Sequence=VSP 029797, VSP 029800, VSP 029801;||TISSUE SPECIFICITY:Expressed in liver, as well as fetal and adult colon and kidney.||SIMILARITY:Belongs to the ligand-gated ion channel (TC

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

5-hydroxytryptamine (serotonin) receptor 3 family member D

Protein sequence

MQKHSPGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVD PAAFQAVFDRKAIGPVTNYSVATHVNISFTLSAIWNCYS RIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLW LSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSAS ANWTPSISPSMDRGRAWRRMSRSFQIHHRTSFRTRREWV LLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVN FLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVF LLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALC LSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHC TGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMP GPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMD ALLFRLYLLFMASSIITVICLWNT

Database cross reference

RefSeq Protein accession:NP_001157118
RefSeq Protein gi:254692968

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;TAS:Reactome.

GO-F

GO:0005230;F:extracellular ligand-gated ion channel activity;IEA:InterPro. GO:0004872;F:receptor activity;IEA:UniProtKB-KW.