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Protein basic information

LiverAtlas Protein ID

HuLPr00087

Uniprot ID

5NT3_HUMAN

Uniprot Acc

Q9H0P0;A8K253;B2RAA5;B8ZZC4;Q6IPZ1;Q6NXS6;Q7L3G6;Q9P0P5;Q9UC42;Q9UC43;Q9UC44;Q9UC45;

Protein name

Cytosolic 5'-nucleotidase 3

Comment

FUNCTION:Can act both as nucleotidase and as phosphotransferase.||CATALYTIC ACTIVITY:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=66 uM for CMP;||SUBUNIT:Monomer.||SUBCELLULAR LOCATION:Cytoplasm (Potential).||SUBCELLULAR LOCATION:Isoform 2:Endoplasmic reticulum.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=2; IsoId=Q9H0P0-4; Sequence=Displayed; Name=1; IsoId=Q9H0P0-1; Sequence=VSP 021565; Name=3; IsoId=Q9H0P0-2; Sequence=VSP 015623; Name=4; Synonyms=P5N-R; IsoId=Q9H0P0-3; Sequence=VSP 015624;||TISSUE SPECIFICITY:Isoform 1 and isoform 3 are expressed in reticulocytes and lymphocytes. Isoform 4 is expressed only in reticulocytes.||INDUCTION:Isoform 2 is induced by interferon alpha in Raji cells in association with lupus inclusions.||DISEASE:Defects in NT5C3 are the cause of P5N deficiency (P5ND) [MIM:266120]; also called hemolytic anemia due to P5N deficiency or hemolytic anemia due

Subcellular localization

Cytoplasm(Potential).

Gene name

5'-nucleotidase, cytosolic III

Protein sequence

MRAPSMDRAAVARVGAVASASVCALVAGVVLAQYIFTLKR KTGRKTKIIEMMPEFQKSSVRIKNPTRVEEIICGLIKGG AAKLQIITDFDMTLSRFSYKGKRCPTCHNIIDNCKLVTD ECRKKLLQLKEKYYAIEVDPVLTVEEKYPYMVEWYTKSH GLLVQQALPKAKLKEIVAESDVMLKEGYENFFDKLQQHS IPVFIFSAGIGDVLEEVIRQAGVYHPNVKVVSNFMDFDE TGVLKGFKGELIHVFNKHDGALRNTEYFNQLKDNSNIIL LGDSQGDLRMADGVANVEHILKIGYLNDRVDELLEKYMD SYDIVLVQDESLEVANSILQKIL

Database cross reference

RefSeq Protein accession:NP_001002010
RefSeq Protein gi:70608082

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005829;C:cytosol;TAS:Reactome. GO:0005783;C:endoplasmic reticulum;IDA:UniProtKB.

GO-F

GO:0008665;F:2'-phosphotransferase activity;NAS:UniProtKB. GO:0008253;F:5'-nucleotidase activity;IDA:UniProtKB. GO:0000287;F:magnesium ion binding;NAS:UniProtKB. GO:0000166;F:nucleotide binding;IEA:UniProtKB-KW.

GO-P

GO:0009117;P:nucleotide metabolic process;IEA:UniProtKB-KW. GO:0006206;P:pyrimidine base metabolic process;TAS:Reactome. GO:0046135;P:pyrimidine nucleoside catabolic process;TAS:Reactome.