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Protein basic information

LiverAtlas Protein ID

HuLPr00290

Uniprot ID

A0S2P1_HUMAN

Uniprot Acc

A0S2P1;

Protein name

Cytochrome c oxidase subunit 2

Comment

FUNCTION:Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 (By similarity).||COFACTOR:Copper A (By similarity).||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).||SIMILARITY:Belongs to the cytochrome c oxidase subunit 2 family.

Subcellular localization

Mitochondrion inner membrane;Multi-pass membrane protein(By similarity).

Gene name

cytochrome c oxidase subunit II

Protein sequence

MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLY ALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALP SLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIF NSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQ DVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQC SEICGANHSFMPIVLELIPLKIFETGPVFTL

Database cross reference

RefSeq Protein accession:YP_003024029
RefSeq Protein gi:251831110

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell. GO:0070469;C:respiratory chain;IEA:UniProtKB-KW.

GO-F

GO:0005507;F:copper ion binding;IEA:InterPro. GO:0004129;F:cytochrome-c oxidase activity;IEA:InterPro. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro.

GO-P

GO:0022904;P:respiratory electron transport chain;IEA:InterPro.