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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr00483

Uniprot ID

A1L467_HUMAN

Uniprot Acc

A1L467;

Protein name

Met proto-oncogene (Hepatocyte growth factor receptor)

Comment

CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SIMILARITY:Belongs to the protein kinase superfamily. Tyr protein kinase family.||SIMILARITY:Contains 1 Sema domain.||SIMILARITY:Contains 1 protein kinase domain.

Gene name

met proto-oncogene (hepatocyte growth factor receptor)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMK YQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQ KVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINM ALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSE VHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFF VGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYI DVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTF HTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEV FNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPD SAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYG PNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLF MGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSR SGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGK KITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVR SEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGW DFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCT VGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISP KYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVS NSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDP IVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHE AGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAF FMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLE IKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPN DLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAG VVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVH TPHLDRLVSARSVSPTTEMVSNES

Database cross reference

RefSeq Protein accession:NP_000236
RefSeq Protein gi:42741655

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004714;F:transmembrane receptor protein tyrosine kinase activity;IEA:InterPro.

GO-P

GO:0007275;P:multicellular organismal development;IEA:InterPro. GO:0006468;P:protein phosphorylation;IEA:InterPro. GO:0007169;P:transmembrane receptor protein tyrosine kinase signaling pathway;IEA:InterPro.

Pathway

Pathway name

IL4

Pathway name

EGFR1