Protein basic information
| LiverAtlas Protein ID |
HuLPr00832 |
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Uniprot ID |
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Uniprot Acc |
P05067;B2R5V1;D3DSD1;D3DSD2;D3DSD3;P09000;P78438;Q13764;Q13778;Q13793;Q16011;Q16014;Q16019;Q16020;Q6GSC0;Q8WZ99;Q9BT38;Q9UC33;Q9UCA9;Q9UCB6;Q9UCC8;Q9UCD1;Q9UQ58; |
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Protein name |
Amyloid beta A4 protein |
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Comment |
FUNCTION:Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms th |
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Subcellular localization |
Membrane;Single-pass type I membrane protein.Membrane, clathrin-coated pit. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGR LNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPE LQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCL VGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKET CSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNV DSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA EVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIAT TTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE GKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKT TQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHF QKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKA VIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHT LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSL LYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRI SYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFG ADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTE EISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAII GLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAV TPEERHLSKMQQNGYENPTYKFFEQMQN |
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Database cross reference |
RefSeq Protein accession:NP_000475
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0030424;C:axon;ISS:UniProtKB. GO:0009986;C:cell surface;IDA:UniProtKB. GO:0005905;C:coated pit;IEA:UniProtKB-SubCell. GO:0043198;C:dendritic shaft;IDA:MGI. GO:0043197;C:dendritic spine;IDA:MGI. GO:0005576;C:extracellular region;EXP:Reactome. GO:00 |
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GO-F |
GO:0033130;F:acetylcholine receptor binding;IPI:UniProtKB. GO:0003677;F:DNA binding;ISS:UniProtKB. GO:0008201;F:heparin binding;IEA:UniProtKB-KW. GO:0042802;F:identical protein binding;IPI:IntAct. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:00 |
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GO-P |
GO:0008 |