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Protein basic information

LiverAtlas Protein ID

HuLPr01389

Uniprot ID

A6NDY6_HUMAN

Uniprot Acc

A6NDY6;

Protein name

Phosphorylase

Comment

FUNCTION:Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity).||CATALYTIC ACTIVITY:(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4- alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.||COFACTOR:Pyridoxal phosphate (By similarity).||SIMILARITY:Belongs to the glycogen phosphorylase family.

Gene name

phosphorylase, glycogen, muscle

Protein sequence

MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTL VKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKD PKKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGH VEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLW SAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPND NFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPV RTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDW DKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHL QIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRI NMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHK FQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQ LRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVH INPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPN KFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDP AVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEA SGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFG MRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFS PKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSAL YKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI

Database cross reference

RefSeq Protein accession:NP_001158188
RefSeq Protein gi:257900462

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0004645;F:phosphorylase activity;IEA:EC. GO:0030170;F:pyridoxal phosphate binding;IEA:InterPro.

GO-P

GO:0005975;P:carbohydrate metabolic process;IEA:UniProtKB-KW.