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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr01426

Uniprot ID

A6NFM2_HUMAN

Uniprot Acc

A6NFM2;

Protein name

Pyrroline-5-carboxylate reductase

Comment

CATALYTIC ACTIVITY:L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H.||PATHWAY:Amino-acid biosynthesis; L-proline biosynthesis; L- proline from L-glutamate 5-semialdehyde:step 1/1.||SIMILARITY:Belongs to the pyrroline-5-carboxylate reductase family.

Gene name

pyrroline-5-carboxylate reductase 1

Protein sequence

MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLA TVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFIL DEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVI RCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVG FCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMG LPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPG GATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQ EQVSPAAIKKTILDKDHLPLELGSPEGLHPLLLQYQLARAPS

Database cross reference

RefSeq Protein accession:NP_008838
RefSeq Protein gi:24797097

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-F

GO:0005488;F:binding;IEA:InterPro. GO:0004735;F:pyrroline-5-carboxylate reductase activity;IEA:EC.

GO-P

GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0006561;P:proline biosynthetic process;IEA:UniProtKB-KW.