HuLPr02529

Uniprot ID

A8K4H7_HUMAN

Uniprot Acc

A8K4H7;

Protein name

Amidophosphoribosyltransferase

Comment

CATALYTIC ACTIVITY:5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.||COFACTOR:Binds 1 4Fe-4S cluster per subunit (By similarity).||COFACTOR:Binds 1 magnesium ion per subunit (By similarity).||PATHWAY:Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate:step 1/2.||SIMILARITY:In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Gene name

phosphoribosyl pyrophosphate amidotransferase

Protein sequence

MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGL QHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNL KKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIA VAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAY TPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYA VRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSE SCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEG NPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIE APVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRY VGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDS IVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGI NIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSV QEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW

Database cross reference

RefSeq Protein accession:NP_002694
RefSeq Protein gi:29570798

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO-F

GO:0004044;F:amidophosphoribosyltransferase activity;IEA:EC. GO:0051536;F:iron-sulfur cluster binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0009116;P:nucleoside metabolic process;IEA:InterPro. GO:0009113;P:purine base biosynthetic process;IEA:InterPro. GO:0006164;P:purine nucleotide biosynthetic process;IEA:UniProtKB-KW.

Glutamate_Metabolism

EGFR1