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Protein basic information

LiverAtlas Protein ID

HuLPr03489

Uniprot ID

A8YQE4_HUMAN

Uniprot Acc

A8YQE4;

Protein name

Interferon gamma

Comment

FUNCTION:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).||SUBUNIT:Homodimer (By similarity).||SUBCELLULAR LOCATION:Secreted (By similarity).||SIMILARITY:Belongs to the type II (or gamma) interferon family.

Subcellular localization

Secreted(By similarity).

Gene name

interferon, gamma

Protein sequence

MKYTSYILAFQXCIVLGSLGCYCQDPYVKEAENLKKYFNA GHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKL FKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKL TNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQM LFRGRRASQ

Database cross reference

RefSeq Protein accession:NP_000610
RefSeq Protein gi:56786138

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0005133;F:interferon-gamma receptor binding;IEA:InterPro.

GO-P

GO:0006955;P:immune response;IEA:InterPro. GO:0040008;P:regulation of growth;IEA:UniProtKB-KW. GO:0009615;P:response to virus;IEA:UniProtKB-KW.