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Protein basic information

LiverAtlas Protein ID

HuLPr03495

Uniprot ID

A8YXX4_HUMAN

Uniprot Acc

A8YXX4;

Protein name

Glutamine synthetase

Comment

CATALYTIC ACTIVITY:ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.||SUBUNIT:Homooctamer (By similarity).||SIMILARITY:Belongs to the glutamine synthetase family.

Gene name

glutamate-ammonia ligase

Protein sequence

MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGL RCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYL VPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCK RIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGP QGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAE VMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVI ATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAI EKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFS AGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVT EALIRTCLLNETGDEPFQYKN

Database cross reference

RefSeq Protein accession:NP_001028216
RefSeq Protein gi:74271837

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005794;C:Golgi apparatus;IDA:HPA.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004356;F:glutamate-ammonia ligase activity;IEA:EC.

GO-P

GO:0006542;P:glutamine biosynthetic process;IEA:InterPro.

Pathway

Pathway name

Ammonia_Recycling

Pathway name

Glutamate_Metabolism