Protein basic information
| LiverAtlas Protein ID |
HuLPr03577 |
|
Uniprot ID |
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Uniprot Acc |
Q2M2I8;Q4ZFZ3;Q53RX6;Q9UPV4; |
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Protein name |
AP2-associated protein kinase 1 |
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Comment |
FUNCTION:Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity).||CATALYTIC ACTIVITY:ATP + a protein = ADP + a phosphoprotein.||ENZYME REGULATION:Stimulated by clathrin (By similarity).||SUBUNIT:Interacts with alpha-adaptin and AP-2 (By similarity).||SUBCELLULAR LOCATION:Membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Active when found in clathrin-coated pits at the plasma membrane (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2M2I8-1; Sequence=Displayed; Name=2; IsoId=Q2M2I8-2; Sequence=VSP 039459;||PTM:Autophosphorylated (By similarity).||SIMILARITY:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.||SIMILARITY:Contains 1 protein kinase domain.||SEQUENCE CAUTION:Sequence=BAA83000 |
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Subcellular localization |
Membrane;Peripheral membrane protein(By similarity).Cell membrane;Peripheral membrane protein(By similarity).Membrane, clathrin-coated pit(By similarity). |
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Gene name |
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Protein sequence
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MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFG IGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVN NEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGD VWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCD TCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFG SATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNF TIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFK LLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKAR LTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPR KRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQ TQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFL KQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQ KPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQL ATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPA PAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSP KTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEAS LNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNF SKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQST QGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIP LQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDA VIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSL TGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDS NLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNS SGSSESSLPNLARSLLLVDQLIDL |
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Database cross reference |
RefSeq Protein accession:NP_055726
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005905;C:coated pit;IEA:UniProtKB-SubCell. GO:0005739;C:mitochondrion;IDA:HPA. GO:0005886;C:plasma membrane;IDA:HPA. |
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GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004674;F:protein serine/threonine kinase activity;IEA:UniProtKB-KW. |
|
GO-P |
GO:0006468;P:protein phosphorylation;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr03577 |
PHOSPHORYLATION |
21 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
221 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
222 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
234 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
235 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
389 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
618 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
623 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
637 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
640 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
606 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
620 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
624 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
670 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
676 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
678 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
624 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
620 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
253 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
327 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
14 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
20 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
18 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
652 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
618 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
670 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
676 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
678 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
606 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
668 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
674 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
627 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
637 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
441 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
292 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
682 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
687 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
690 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
640 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
642 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
623 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
235 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
234 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
34 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
21 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
389 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
354 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
362 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
731 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
650 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03577 |
PHOSPHORYLATION |
653 |
T |
PhosphoSitePlus |
LTP |
N |
|
