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Protein basic information

LiverAtlas Protein ID

HuLPr03586

Uniprot ID

AASD1_HUMAN

Uniprot Acc

Q9BTE6;

Protein name

Alanyl-tRNA editing protein Aarsd1

Comment

FUNCTION:Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) (By similarity).||COFACTOR:Binds 1 zinc ion per subunit (Potential).||SUBCELLULAR LOCATION:Cytoplasm (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BTE6-1; Sequence=Displayed; Name=2; IsoId=Q9BTE6-2; Sequence=VSP 023014;||SIMILARITY:Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

Subcellular localization

Cytoplasm(By similarity).

Gene name

alanyl-tRNA synthetase domain containing 1

Protein sequence

MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSG FQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQA DHFTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAV ADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQS VNEKIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPI RVVNIEGVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNR TNLIFLSGNRVLKWMERSHGTEKALTALLKCGAEDHVEA VKKLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPDWGGV VILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGL FLLAGPPASVETLGPRVAEVLEGKGAGKKGRFQGKATKM SRRMEAQALLQDYISTQSAKE

Database cross reference

RefSeq Protein accession:NP_001129514
RefSeq Protein gi:217416402

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0004813;F:alanine-tRNA ligase activity;IEA:InterPro. GO:0005524;F:ATP binding;IEA:InterPro. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0003676;F:nucleic acid binding;IEA:InterPro.

GO-P

GO:0006419;P:alanyl-tRNA aminoacylation;IEA:InterPro.