HuLPr03598

Uniprot ID

ABC3F_HUMAN

Uniprot Acc

Q8IUX4;B0QYD4;Q45F03;Q7Z2N2;Q7Z2N5;

Protein name

DNA dC->dU-editing enzyme APOBEC-3F

Comment

FUNCTION:After being packaged into HIV-1 virions, blocks productive infection by massively editing dC residues to dU on the DNA minus strand during reverse transcription. The editing of the minus strand DNA of HIV-1 during reverse transcription leads to G- to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations.||COFACTOR:Zinc (By similarity).||SUBUNIT:Forms heterodimers with APOBEC3G. Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IUX4-1; Sequence=Displayed; Name=2; IsoId=Q8IUX4-2; Sequence=VSP 009803, VSP 009804; Note=May be due to a competing donor splice site. No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed, including in lymphoid tissues, such as thymus and peripheral blood leukocytes. No

Gene name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

Protein sequence

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVK TKGPSRPRLDAKIFRGQVYSQPEHHAEMCFLSWFCGNQL PAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTIS AARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWE NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMY PHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKR GVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWY TSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTD YQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFK PWKGLKYNFLFLDSKLQEILE

Database cross reference

RefSeq Protein accession:NP_001006667
RefSeq Protein gi:54873619

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0030895;C:apolipoprotein B mRNA editing enzyme complex;TAS:HGNC.

GO-F

GO:0004126;F:cytidine deaminase activity;IDA:HGNC. GO:0003723;F:RNA binding;IDA:HGNC. GO:0008270;F:zinc ion binding;IDA:HGNC.

GO-P

GO:0016553;P:base conversion or substitution editing;IDA:HGNC. GO:0045087;P:innate immune response;IDA:HGNC. GO:0045869;P:negative regulation of retroviral genome replication;IDA:HGNC. GO:0002230;P:positive regulation of defense response to virus by hos