HuLPr03604

Uniprot ID

ABCA5_HUMAN

Uniprot Acc

Q8WWZ7;Q8IVJ2;Q96LJ1;Q96MS4;Q96PZ9;Q9NY14;

Protein name

ATP-binding cassette sub-family A member 5

Comment

FUNCTION:May play a role in the processing of autolysosomes (By similarity).||SUBCELLULAR LOCATION:Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WWZ7-1; Sequence=Displayed; Name=2; Synonyms=V20+16; IsoId=Q8WWZ7-2; Sequence=VSP 020691, VSP 020692; Name=3; IsoId=Q8WWZ7-3; Sequence=VSP 020690; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta.||DEVELOPMENTAL STAGE:Expressed in fetal liver, kidney and brain.||PTM:N-glycosylated (By similarity).||SIMILARITY:Belongs to the ABC transporter superfamily. ABCA family.||SIMILARITY:Contains 2 ABC transporter domains.||SEQUENCE CAUTION:Sequence=BAB71700.1; Type=Erroneous initiation;

Subcellular localization

Lysosome membrane;Multi-pass membrane protein.Late endosome membrane;Multi-pass membrane protein.Golgi apparatus membrane;Multi-pass membrane protein(By similarity).

Gene name

ATP-binding cassette, sub-family A (ABC1), member 5

Protein sequence

MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPL FFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLIL GYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTS SLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRA GCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKE LESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYF LAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLI FLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFF ALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFP KSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTA GPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRS SLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVS SEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQ ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSE IDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGI PANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSL GIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANR VTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSK WGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQ QLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTL EDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEME QSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRES KSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPD LYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNI MVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTM VYSLPILVNIISNYYLYHLNVTET

Database cross reference

RefSeq Protein accession:NP_061142
RefSeq Protein gi:27262624

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031902;C:late endosome membrane;IEA:UniProtKB-SubCell. GO:0005765;C:lysosomal membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0016887;F:ATPase activity;IEA:InterPro.

GO-P

GO:0033344;P:cholesterol efflux;ISS:BHF-UCL. GO:0034375;P:high-density lipoprotein particle remodeling;ISS:BHF-UCL. GO:0010745;P:negative regulation of macrophage derived foam cell differentiation;ISS:BHF-UCL. GO:0043691;P:reverse cholesterol transport;

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03604

PHOSPHORYLATION

22

Y

PhosphoSitePlus

1014932

LTP

HTP

N

HuLPr03604

PHOSPHORYLATION

1299

Y

PhosphoSitePlus

472660

LTP

N

HuLPr03604

PHOSPHORYLATION

134

S

PhosphoSitePlus

14567468

LTP

yes

HuLPr03604

PHOSPHORYLATION

137

Y

PhosphoSitePlus

14567471

HTP

yes

HuLPr03604

PHOSPHORYLATION

58

Y

PhosphoSitePlus

1026836

LTP

N

HuLPr03604

ACETYLATION

614

K

PhosphoSitePlus

474879

LTP

N

HuLPr03604

ACETYLATION

620

K

PhosphoSitePlus

474880

LTP

N