Protein basic information
| LiverAtlas Protein ID |
HuLPr03607 |
|
Uniprot ID |
|
|
Uniprot Acc |
O94911;Q86WW0; |
|
Protein name |
ATP-binding cassette sub-family A member 8 |
|
Comment |
FUNCTION:ATP-dependent lipophilic drug transporter.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=30.4 uM for estradiol-beta-glucuronide; KM=0.1 uM for LTC4; KM=10.3 uM for taurochlorate; KM=5.0 uM for PAH; KM=0.5 uM for estrone sulfate; KM=0.4 uM for ochratoxin A;||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O94911-1; Sequence=Displayed; Name=2; IsoId=O94911-2; Sequence=VSP 020703; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed with higher expression in heart, skeletal muscle and liver.||SIMILARITY:Belongs to the ABC transporter superfamily. ABCA family.||SIMILARITY:Contains 2 ABC transporter domains.||SEQUENCE CAUTION:Sequence=BAA74845.2; Type=Erroneous initiation; |
|
Subcellular localization |
Cell membrane;Multi-pass membrane protein(Probable). |
|
Gene name |
|
|
Protein sequence
|
MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLL LLCLYIYPHSHQVNDFSSLLTMDLGRVDTFNESRFSVVY TPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTA NYPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAH CYETNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHS VMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSS FIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYA GFIFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSL VALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRH LPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHP SDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHR RPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQ APPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYE GQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKL SEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIK GILPQEVDKEIFLLDEPTAGLDPFSRHQVWNLLKERKTD RVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKK KWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSE GKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSMTT LNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEM EQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHER KALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHL YFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIA LEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAK RLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQD NPIGFLAYIMFWLVLTSSCPPYIA |
|
Database cross reference |
RefSeq Protein accession:NP_009099
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0042626;F:ATPase activity, coupled to transmembrane movement of substances;IDA:MGI. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr03607 |
PHOSPHORYLATION |
1507 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr03607 |
PHOSPHORYLATION |
256 |
T |
PhosphoSitePlus |
LTP |
N |
|
