HuLPr03608

Uniprot ID

ABCA9_HUMAN

Uniprot Acc

Q8IUA7;Q6P655;Q8N2S4;Q8WWZ5;Q96MD8;

Protein name

ATP-binding cassette sub-family A member 9

Comment

FUNCTION:May play a role in monocyte differentiation and lipid homeostasis.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8IUA7-1; Sequence=Displayed; Name=2; Synonyms=ABCA9delta+55; IsoId=Q8IUA7-2; Sequence=VSP 020705; Name=3; Synonyms=ABCA9delta+73; IsoId=Q8IUA7-3; Sequence=VSP 020707, VSP 020709; Name=4; Synonyms=ABCA9delta-95; IsoId=Q8IUA7-4; Sequence=VSP 020708, VSP 020709; Name=5; IsoId=Q8IUA7-5; Sequence=VSP 020706; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed with higher expression in heart.||DEVELOPMENTAL STAGE:Expressed in fetal tissues with higher expression in fetal heart and kidney.||INDUCTION:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.||SIMILARITY:Belongs to the ABC transporter superfamily. ABCA family.||SIMILARITY:Contains 2 ABC transporter do

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

ATP-binding cassette, sub-family A (ABC1), member 9

Protein sequence

MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLL VLFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDTNYVIA FAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELD LNYSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSA HCQAVNEKMKCEGSEFWEKGFVAFQAAINAAIIEIATNH SVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFS TFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMY AGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLS LITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYT RLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLD SSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGH RCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFE PVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIY EGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHT LSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKI KGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRK LTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGK SDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFL KKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQ SEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSI TTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLV ELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKK ERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSP NTYFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQN IAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACN TKRLNCFPVLLDVISNGLLGIFNS

Database cross reference

RefSeq Protein accession:NP_525022
RefSeq Protein gi:27477115

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0016887;F:ATPase activity;IEA:InterPro.

GO-P

GO:0006810;P:transport;IEA:UniProtKB-KW.