Protein basic information
| LiverAtlas Protein ID |
HuLPr03609 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q8WWZ4;C9JZH2;C9K035;Q6PIQ6;Q7Z2I9;Q7Z7P7;Q86TD2; |
|
Protein name |
ATP-binding cassette sub-family A member 10 |
|
Comment |
FUNCTION:Probable transporter which may play a role in macrophage lipid homeostasis.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8WWZ4-1; Sequence=Displayed; Name=2; Synonyms=ABCA10delta+82; IsoId=Q8WWZ4-2; Sequence=VSP 021061; Name=3; Synonyms=ABCA10delta-104; IsoId=Q8WWZ4-3; Sequence=VSP 021062, VSP 021063; Name=4; Synonyms=ABCA10delta-176; IsoId=Q8WWZ4-4; Sequence=VSP 021065, VSP 021066; Name=5; IsoId=Q8WWZ4-5; Sequence=VSP 021064, VSP 021067; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.||INDUCTION:Down-regulated by cholesterol loading of macrophages.||SIMILARITY:Belongs to the ABC transporter superfamily. ABCA family.||SIMILARITY:Contains 2 ABC transporter domains. |
|
Subcellular localization |
Membrane;Multi-pass membrane protein(Potential). |
|
Gene name |
|
|
Protein sequence
|
MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIF SDTFSYRLKFNWGYRIPVIKEHSEYTEHCWAMHGEIFCY LAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGI NMKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVAR ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMA LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLI RKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSL LSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATF FILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSF WSKHQNTHHEIFENEINPEHSSDDSFEPVSPEFHGKEAI RIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNG AGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRK NIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQ VLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFM DEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSL HRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLE KTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEG KSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPET RKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVL GIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPK TPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNRN GSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMG IVSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSI FLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAY WCGQALVDIPLYFLILFSIHLIYY |
|
Database cross reference |
RefSeq Protein accession:NP_525021
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
French Liver;Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0016887;F:ATPase activity;IEA:InterPro. |
|
GO-P |
GO:0006810;P:transport;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr03609 |
PHOSPHORYLATION |
307 |
Y |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr03609 |
PHOSPHORYLATION |
568 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03609 |
PHOSPHORYLATION |
307 |
Y |
PhosphoSitePlus |
LTP |
N |
|
