Protein basic information
| LiverAtlas Protein ID |
HuLPr03610 |
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Uniprot ID |
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Uniprot Acc |
Q86UK0;Q53QE2;Q53S55;Q8IZW6;Q96JT3;Q9Y4M5; |
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Protein name |
ATP-binding cassette sub-family A member 12 |
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Comment |
FUNCTION:Probable transporter involved in lipid homeostasis.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist; Name=1; IsoId=Q86UK0-1; Sequence=Displayed; Name=2; IsoId=Q86UK0-2; Sequence=VSP 011283, VSP 011284; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Mainly expressed in the stomach, placenta, testis and fetal brain.||DOMAIN:Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity).||DISEASE:Defects in ABCA12 are the cause of ichthyosis harlequin (HI) [MIM:242500]; also known as harlequin fetus. HI is a very severe skin disorder in which the neonate is born with a thick covering of armor-like scales. The skin dries out to form hard diamond-shaped plaques separated by fissures, resembling 'armor plating'. The nor |
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Subcellular localization |
Membrane;Multi-pass membrane protein(Potential). |
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Gene name |
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Protein sequence
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MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIIL AITRTKFPPTAKPTCYLAPRNLPSTGFFPFLQTLLCDTD SKCKDTPYGPQDLLRRKGIDDALFKDSEILRKSSNLDKD SSLSFQSTQVPERRHASLATVFPSPSSDLEIPGTYTFNG SQVLARILGLEKLLKQNSTSEDIRRELCDSYSGYIVDDA FSWTFLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSD PNNQKIVFQEIVRMLSFFSQVQEQKAVWQLLSSFPNVFQ NDTSLSNLFDVLRKANSVLLVVQKVYPRFATNEGFRTLQ KSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLA AQLLILENFEDALLNISANSPYIPYLACVRNVTDSLARG SPENLRLLQSTIRFKKSFLRNGSYEDYFPPVPEVLKSKL SQLRNLTELLCESETFSLIEKSCQLSDMSFGSLCEESEF DLQLLEAAELGTEIAASLLYHDNVISKKVRDLLTGDPSK INLNMDQFLEQALQMNYLENITQLIPIIEAMLHVNNSAD ASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAI PIPDNRAEIISQVFWLHSCDTNITTPKLEDAMKEFCNLS LSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKPVE KMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSV PLTQAMYRSNRMNTPQGSFSTISQALCSQGITTEYLTAM LPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPFC FSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKA IMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQA IPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILR LKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTID EMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVF LPPVIKYTIRMSLKTAQTTRSLRT |
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Database cross reference |
RefSeq Protein accession:NP_056472
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver;Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;NAS:UniProtKB. |
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GO-F |
GO:0005524;F:ATP binding;NAS:UniProtKB. GO:0016887;F:ATPase activity;IEA:InterPro. |
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GO-P |
GO:0019725;P:cellular homeostasis;NAS:UniProtKB. GO:0006869;P:lipid transport;NAS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr03610 |
PHOSPHORYLATION |
1488 |
S |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr03610 |
PHOSPHORYLATION |
811 |
Y |
PhosphoSitePlus |
LTP |
N |
|
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HuLPr03610 |
PHOSPHORYLATION |
814 |
Y |
PhosphoSitePlus |
LTP |
N |
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