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Protein basic information

LiverAtlas Protein ID

HuLPr03644

Uniprot ID

ABHD4_HUMAN

Uniprot Acc

Q8TB40;Q9H9E0;

Protein name

Abhydrolase domain-containing protein 4

Comment

FUNCTION:Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).||SIMILARITY:Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.||CAUTION:Thr-291 is present instead of the conserved His which is expected to be an active site residue.

Gene name

abhydrolase domain containing 4

Protein sequence

MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQ NKFLARYVSLPNQNKIWTVTVSPEQNDRTPLVMVHGFGG GVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPE GAEDEFVTSIETWRETMGIPSMILLGHSLGGFLATSYSI KYPDRVKHLILVDPWGFPLRPTNPSEIRAPPAWVKAVAS VLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFED DTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERI HLIRKDVPITMIYGSDTWIDTSTGKKVKMQRPDSYVRDM EIKGASHHVYADQPHIFNAVVEEICDSVD

Database cross reference

RefSeq Protein accession:NP_071343
RefSeq Protein gi:50658087

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0016787;F:hydrolase activity;IEA:UniProtKB-KW.

GO-P

GO:0016042;P:lipid catabolic process;IEA:UniProtKB-KW.