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Protein basic information

LiverAtlas Protein ID

HuLPr03664

Uniprot ID

ABRA_HUMAN

Uniprot Acc

Q8N0Z2;

Protein name

Actin-binding Rho-activating protein

Comment

FUNCTION:Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity).||SUBUNIT:Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By similarity).||SUBCELLULAR LOCATION:Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines (By similarity).

Subcellular localization

Cytoplasm, myofibril, sarcomere(By similarity).Cytoplasm, cytoskeleton(By similarity).

Gene name

actin-binding Rho activating protein

Protein sequence

MAPGEKESGEGPAKSALRKIRTATLVISLARGWQQWANEN SIRQAQEPTGWLPGGTQDSPQAPKPITPPTSHQKAQSAP KSPPRLPEGHGDGQSSEKAPEVSHIKKKEVSKTVVSKTY ERGGDVSHLSHRYERDAGVLEPGQPENDIDRILHSHGSP TRRRKCANLVSELTKGWRVMEQEEPTWRSDSVDTEDSGY GGEAEERPEQDGVQVAVVRIKRPLPSQVNRFTEKLNCKA QQKYSPVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELA MSTRLHKGDEGYGRPKEGTKTAERAKRAEEHIYREMMDM CFIICTMARHRRDGKIQVTFGDLFDRYVRISDKVVGILM RARKHGLVDFEGEMLWQGRDDHVVITLLK

Database cross reference

RefSeq Protein accession:NP_631905
RefSeq Protein gi:21040251

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0015629;C:actin cytoskeleton;ISS:HGNC. GO:0005886;C:plasma membrane;IDA:LIFEdb. GO:0030017;C:sarcomere;ISS:HGNC.

GO-F

GO:0003779;F:actin binding;ISS:HGNC.

GO-P

GO:0035025;P:positive regulation of Rho protein signal transduction;ISS:HGNC. GO:0051091;P:positive regulation of sequence-specific DNA binding transcription factor activity;ISS:HGNC. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. GO:005508

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03664

PHOSPHORYLATION

286

Y

PhosphoSitePlus

974097

LTP

N