Protein basic information
LiverAtlas Protein ID |
HuLPr03664 |
Uniprot ID |
|
Uniprot Acc |
Q8N0Z2; |
Protein name |
Actin-binding Rho-activating protein |
Comment |
FUNCTION:Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity).||SUBUNIT:Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By similarity).||SUBCELLULAR LOCATION:Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines (By similarity). |
Subcellular localization |
Cytoplasm, myofibril, sarcomere(By similarity).Cytoplasm, cytoskeleton(By similarity). |
Gene name |
|
Protein sequence
|
MAPGEKESGEGPAKSALRKIRTATLVISLARGWQQWANEN SIRQAQEPTGWLPGGTQDSPQAPKPITPPTSHQKAQSAP KSPPRLPEGHGDGQSSEKAPEVSHIKKKEVSKTVVSKTY ERGGDVSHLSHRYERDAGVLEPGQPENDIDRILHSHGSP TRRRKCANLVSELTKGWRVMEQEEPTWRSDSVDTEDSGY GGEAEERPEQDGVQVAVVRIKRPLPSQVNRFTEKLNCKA QQKYSPVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELA MSTRLHKGDEGYGRPKEGTKTAERAKRAEEHIYREMMDM CFIICTMARHRRDGKIQVTFGDLFDRYVRISDKVVGILM RARKHGLVDFEGEMLWQGRDDHVVITLLK |
Database cross reference |
RefSeq Protein accession:NP_631905
|
Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0015629;C:actin cytoskeleton;ISS:HGNC. GO:0005886;C:plasma membrane;IDA:LIFEdb. GO:0030017;C:sarcomere;ISS:HGNC. |
GO-F |
GO:0003779;F:actin binding;ISS:HGNC. |
GO-P |
GO:0035025;P:positive regulation of Rho protein signal transduction;ISS:HGNC. GO:0051091;P:positive regulation of sequence-specific DNA binding transcription factor activity;ISS:HGNC. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. GO:005508 |
Post-translational modification
LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
HuLPr03664 |
PHOSPHORYLATION |
286 |
Y |
PhosphoSitePlus |
LTP |
N |