HuLPr03677

Uniprot ID

ACAP2_HUMAN

Uniprot Acc

Q15057;A8K2V4;Q8N5Z8;Q9UQR3;

Protein name

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Comment

FUNCTION:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).||ENZYME REGULATION:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.||TISSUE SPECIFICITY:Widely expressed. Highest level in lung.||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Contains 3 ANK repeats.||SIMILARITY:Contains 1 Arf-GAP domain.||SIMILARITY:Contains 1 BAR domain.||SIMILARITY:Contains 1 PH domain.||SEQUENCE CAUTION:Sequence=BAA05064.2; Type=Erroneous initiation; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111;

Gene name

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Protein sequence

MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVK LCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETS LTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLR KFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATN ILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFM YAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEK REMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLF KRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDL RLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAW IKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNES KEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLG ITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE LGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYV ERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPG DQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLY EPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEA LAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNG ANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHAT DEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLY GQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF

Database cross reference

RefSeq Protein accession:NP_036419
RefSeq Protein gi:187608516

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO-F

GO:0008060;F:ARF GTPase activator activity;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0032312;P:regulation of ARF GTPase activity;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03677

PHOSPHORYLATION

379

S

Phospho-ELM

5637

HTP

N

HuLPr03677

PHOSPHORYLATION

384

S

Phospho-ELM

5638

HTP

N

HuLPr03677

PHOSPHORYLATION

742

Y

Phospho-ELM

4537

HTP

N

HuLPr03677

PHOSPHORYLATION

750

Y

Phospho-ELM

4538

HTP

N

HuLPr03677

PHOSPHORYLATION

378

S

Phospho-ELM

35350

HTP

N

HuLPr03677

PHOSPHORYLATION

586

Y

PhosphoSitePlus

475223

LTP

N

HuLPr03677

PHOSPHORYLATION

521

S

PhosphoSitePlus

486233

LTP

N

HuLPr03677

PHOSPHORYLATION

379

S

PhosphoSitePlus

452425

LTP

N

HuLPr03677

PHOSPHORYLATION

384

S

PhosphoSitePlus

452426

LTP

HTP

N

HuLPr03677

PHOSPHORYLATION

378

S

PhosphoSitePlus

1855451

LTP

N

HuLPr03677

PHOSPHORYLATION

387

S

PhosphoSitePlus

1855455

LTP

N

HuLPr03677

PHOSPHORYLATION

775

S

PhosphoSitePlus

481909

LTP

N

HuLPr03677

PHOSPHORYLATION

742

Y

PhosphoSitePlus

448998

LTP

N

HuLPr03677

PHOSPHORYLATION

750

Y

PhosphoSitePlus

448999

LTP

N

Arf6_signaling_events