HuLPr03689

Uniprot ID

ACCN3_HUMAN

Uniprot Acc

Q9UHC3;B2R9V0;O60263;O75906;Q59FN9;Q9UER8;Q9UHC4;

Protein name

Amiloride-sensitive cation channel 3

Comment

FUNCTION:Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.||SUBUNIT:Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ACCN1.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named i

Subcellular localization

Cell membrane;Multi-pass membrane protein(By similarity).Cytoplasm(By similarity).

Gene name

amiloride-sensitive cation channel 3

Protein sequence

MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSL RRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDER ESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD PAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSL DDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGA ELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEV GIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF LPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLM GCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAH PAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAAR FLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYE MSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVL GYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPP TPPCAVTKTLSASHRTCYLVTQL

Database cross reference

RefSeq Protein accession:NP_004760
RefSeq Protein gi:4757710

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0015280;F:ligand-gated sodium channel activity;IEA:InterPro.

GO-P

GO:0007600;P:sensory perception;TAS:ProtInc. GO:0007165;P:signal transduction;TAS:ProtInc.