Protein basic information
| LiverAtlas Protein ID |
HuLPr03722 |
|
Uniprot ID |
|
|
Uniprot Acc |
P53396;Q13037;Q9BRL0; |
|
Protein name |
ATP-citrate synthase |
|
Comment |
FUNCTION:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.||CATALYTIC ACTIVITY:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.||SUBUNIT:Homotetramer.||INTERACTION:P49841:GSK3B; NbExp=1; IntAct=EBI-1042794, EBI-373586; Q14164:IKBKE; NbExp=1; IntAct=EBI-1042794, EBI-307369; P22392:NME2; NbExp=1; IntAct=EBI-1042794, EBI-713693; Q9Y478:PRKAB1; NbExp=1; IntAct=EBI-1042794, EBI-719769; P19532:TFE3; NbExp=1; IntAct=EBI-1042794, EBI-1048957;||SUBCELLULAR LOCATION:Cytoplasm.||PTM:ISGylated.||SIMILARITY:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.||SIMILARITY:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. |
|
Subcellular localization |
Cytoplasm. |
|
Gene name |
|
|
Related liver disease name |
|
|
Protein sequence
|
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDW ARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLD GVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEE FYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVD EKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLY FTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGD IEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGR IWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSE QQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAA TFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVM GEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPT AAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKK AKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRA VQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKE ILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETM NYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPAT VGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSG GMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLR YQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVC WCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKE AGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPT VPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPI TEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTA DHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGG ALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHR VKSINNPDMRVQILKDYVRQHFPA |
|
Database cross reference |
RefSeq Protein accession:NP_001087
|
Liver relevance
|
HCC significant Proteins |
Yes/No |
Yes |
|
Quality score |
|
|
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0009346;C:citrate lyase complex;TAS:ProtInc. GO:0005829;C:cytosol;EXP:Reactome. GO:0005634;C:nucleus;IDA:HPA. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0003878;F:ATP citrate synthase activity;TAS:ProtInc. GO:0008815;F:citrate (pro-3S)-lyase activity;EXP:Reactome. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:IntAct. GO: |
|
GO-P |
GO:0006200;P:ATP catabolic process;TAS:ProtInc. GO:0044262;P:cellular carbohydrate metabolic process;IEA:InterPro. GO:0006101;P:citrate metabolic process;TAS:ProtInc. GO:0015936;P:coenzyme A metabolic process;TAS:ProtInc. |