Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr03731

Uniprot ID

ACO12_HUMAN

Uniprot Acc

Q8WYK0;B3KVK9;

Protein name

Acyl-coenzyme A thioesterase 12

Comment

FUNCTION:Hydrolyzes acetyl-CoA to acetate and CoA.||CATALYTIC ACTIVITY:Acetyl-CoA + H(2)O = CoA + acetate.||ENZYME REGULATION:Inhibited by ADP. Active in the presence of ATP.||PATHWAY:Carbohydrate metabolism; pyruvate metabolism.||SUBUNIT:Homodimer or homotetramer (By similarity).||SUBCELLULAR LOCATION:Cytoplasm.||SIMILARITY:Contains 2 acyl coenzyme A hydrolase domains.||SIMILARITY:Contains 1 START domain.

Subcellular localization

Cytoplasm.

Gene name

acyl-CoA thioesterase 12

Protein sequence

MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTAC LAAEKHAGVSCVTASVDDIQFEETARVGQVITIKAKVTR AFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGK EKIHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNL MKESSKFDDLIFDEEEGAVSTRGTSVQSIELVLPPHANH HGNTFGGQIMAWMETVATISASRLCWAHPFLKSVDMFKF RGPSTVGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWA EGRGRHINSAFLIYNAADDKENLITFPRIQPISKDDFRR YRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLS DSNVEALKKLAAKRGWEVTSTVEKIKIYTLEEHDVLSVW VEKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVS EDDQLYHITCPILNDDKPKDLVVLVSRRKPLKDGNTYTV AVKSVILPSVPPSPQYIRSEIICAGFLIHAIDSNSCIVS YFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENPPDDGFVSTF

Database cross reference

RefSeq Protein accession:NP_570123
RefSeq Protein gi:18640736

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005829;C:cytosol;ISS:HGNC.

GO-F

GO:0003986;F:acetyl-CoA hydrolase activity;ISS:HGNC. GO:0004091;F:carboxylesterase activity;IEA:UniProtKB-KW.

GO-P

GO:0006637;P:acyl-CoA metabolic process;ISS:HGNC. GO:0006631;P:fatty acid metabolic process;IEA:UniProtKB-KW.

Pathway

Pathway name

Pyruvate_Metabolism

Pathway name

Leigh_Syndrome