Protein basic information
| LiverAtlas Protein ID |
HuLPr03733 |
|
Uniprot ID |
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Uniprot Acc |
P21399;D3DRK7;Q14652;Q5VZA7; |
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Protein name |
Cytoplasmic aconitate hydratase |
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Comment |
FUNCTION:Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.||FUNCTION:Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).||CATALYTIC ACTIVITY:Citrate = isocitrate.||COFACTOR:Binds 1 4Fe-4S cluster per subunit.||SUBUNIT:Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).||SUBCELLULAR LOCATION:Cytoplasm.||SIMILARITY:Belongs to the aconitase/IPM isomerase family.||WEB RESOURCE:Name=Wikipedia; Note=Aconitase entry; URL="http://en.wikipedia.org/wiki/Aconitase"; |
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Subcellular localization |
Cytoplasm. |
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Gene name |
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Protein sequence
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MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIR VLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFK PARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVC PADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFL KWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYY YPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPI SMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVV GKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVD EVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQD PDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFES CLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVV IAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKT SLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIG NSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTR ANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFL KDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNA LATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVD AYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTP REFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTI HLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRD WAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLP GENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTF QAVMRFDTDVELTYFLNGGILNYMIRKMAK |
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Database cross reference |
RefSeq Protein accession:NP_002188
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IDA:HGNC. GO:0005783;C:endoplasmic reticulum;IDA:MGI. GO:0005794;C:Golgi apparatus;IDA:MGI. |
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GO-F |
GO:0051539;F:4 iron, 4 sulfur cluster binding;IDA:UniProtKB. GO:0003994;F:aconitate hydratase activity;IDA:UniProtKB. GO:0052632;F:citrate hydro-lyase (cis-aconitate-forming) activity;IEA:EC. GO:0030350;F:iron-responsive element binding;IDA:UniProtKB. |
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GO-P |
GO:0006101;P:citrate metabolic process;IDA:UniProtKB. GO:0010040;P:response to iron(II) ion;IDA:UniProtKB. GO:0006099;P:tricarboxylic acid cycle;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr03733 |
PHOSPHORYLATION |
138 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr03733 |
PHOSPHORYLATION |
711 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr03733 |
PHOSPHORYLATION |
759 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr03733 |
PHOSPHORYLATION |
466 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03733 |
PHOSPHORYLATION |
711 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03733 |
PHOSPHORYLATION |
383 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr03733 |
PHOSPHORYLATION |
138 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
