HuLPr03758

Uniprot ID

ACSF4_HUMAN

Uniprot Acc

Q4L235;A5D8V3;A5PL22;Q63HK2;Q63HR7;Q6IPP8;Q6TFZ6;Q7Z5Y3;Q96BW4;Q9P064;

Protein name

Acyl-CoA synthetase family member 4

Comment

FUNCTION:Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4L235-1; Sequence=Displayed; Name=2; IsoId=Q4L235-2; Sequence=VSP 030707; Note=No experimental confirmation available; Name=3; IsoId=Q4L235-3; Sequence=VSP 030711, VSP 030712; Name=4; IsoId=Q4L235-4; Sequence=VSP 030710, VSP 030713; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Ubiquitously expressed in adult tissues.||SIMILARITY:Belongs to the ATP-dependent AMP-binding enzyme family.||SIMILARITY:Contains 1 acyl carrier domain.||SEQUENCE CAUTION:Sequence=CAH56482.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Gene name

aminoadipate-semialdehyde dehydrogenase

Protein sequence

MTLQELVHKAASCYMDRVAVCFDECNNQLPVYYTYKTVVN AASELSNFLLLHCDFQGIREIGLYCQPGIDLPSWILGIL QVPAAYVPIEPDSPPSLSTHFMKKCNLKYILVEKKQINK FKSFHETLLNYDTFTVEHNDLVLFRLHWKNTEVNLMLND GKEKYEKEKIKSISSEHVNEEKAEEHMDLRLKHCLAYVL HTSGTTGIPKIVRVPHKCIVPNIQHFRVLFDITQEDVLF LASPLTFDPSVVEIFLALSSGASLLIVPTSVKLLPSKLA SVLFSHHRVTVLQATPTLLRRFGSQLIKSTVLSATTSLR VLALGGEAFPSLTVLRSWRGEGNKTQIFNVYGITEVSSW ATIYRIPEKTLNSTLKCELPVQLGFPLLGTVVEVRDTNG FTIQEGSGQVFLGGRNRVCFLDDEVTVPLGTMRATGDFV TVKDGEIFFLGRKDSQIKRHGKRLNIELVQQVAEELQQV ESCAVTWYNQEKLILFMVSKDASVKEYIFKELQKYLPSH AVPDELVLIDSLPFTSHGKIDVSELNKIYLNYINLKSEN KLSGKEDLWEKLQYLWKSTLNLPEDLLRVPDESLFLNSG GDSLKSIRLLSEIEKLVGTSVPGLLEIILSSSILEIYNH ILQTVVPDEDVTFRKSCATKRKLSDINQEEASGTSLHQK AIMTFTCHNEINAFVVLSRGSQILSLNSTRFLTKLGHCS SACPSDSVSQTNIQNLKGLNSPVLIGKSKDPSCVAKVSE EGKPAIGTQKMELHVRWRSDTGKCVDASPLVVIPTFDKS STTVYIGSHSHRMKAVDFYSGKVKWEQILGDRIESSACV SKCGNFIVVGCYNGLVYVLKSNSGEKYWMFTTEDAVKSS ATMDPTTGLIYIGSHDQHAYALDIYRKKCVWKSKCGGTV FSSPCLNLIPHHLYFATLGGLLLAVNPATGNVIWKHSCG KPLFSSPQCCSQYICIGCVDGNLLCFTHFGEQVWQFSTS GPIFSSPCTSPSEQKIFFGSHDCF

Database cross reference

RefSeq Protein accession:NP_861522
RefSeq Protein gi:45580730

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO-F

GO:0016878;F:acid-thiol ligase activity;ISS:UniProtKB. GO:0000036;F:acyl carrier activity;IEA:InterPro. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0048037;F:cofactor binding;IEA:InterPro.

GO-P

GO:0006631;P:fatty acid metabolic process;ISS:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03758

ACETYLATION

591

K

PhosphoSitePlus

14321187

LTP

N

HuLPr03758

PHOSPHORYLATION

194

Y

PhosphoSitePlus

1007829

LTP

HTP

N