HuLPr03759

Uniprot ID

ACSL1_HUMAN

Uniprot Acc

P33121;D3DP57;P41215;Q8N8V7;Q8TA99;

Protein name

Long-chain-fatty-acid--CoA ligase 1

Comment

FUNCTION:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.||CATALYTIC ACTIVITY:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.||COFACTOR:Magnesium.||SUBCELLULAR LOCATION:Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33121-1; Sequence=Displayed; Name=2; IsoId=P33121-2; Sequence=VSP 009604; Note=May be due to a competing acceptor splice site. No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and

Subcellular localization

Mitochondrion outer membrane;Single-pass type III membrane protein(By similarity).Peroxisome membrane;Single-pass type III membrane protein(By similarity).Microsome membrane;Single-pass type III membrane protein(By similarity).Endoplasmic reticulum membrane;Single-pass type III membrane protein(By similarity).

Gene name

acyl-CoA synthetase long-chain family member 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALT TFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSD EPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPY EWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNR PEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELS LVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELV ERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVIC FTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPD DTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLM DDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLD FASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRL MVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCL TMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEV CVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPN GTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQV FVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELC RNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFS IDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV

Database cross reference

RefSeq Protein accession:NP_001986
RefSeq Protein gi:40807491

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;IEA:UniProtKB-SubCell. GO:0005741;C:mitochondrial outer membrane;IEA:UniProtKB-SubCell. GO:0005778;C:peroxisomal membra

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004467;F:long-chain fatty acid-CoA ligase activity;EXP:Reactome.

GO-P

GO:0007586;P:digestion;TAS:ProtInc. GO:0006631;P:fatty acid meta Error!!!Go back to the login page