HuLPr03763

Uniprot ID

ACSL6_HUMAN

Uniprot Acc

Q9UKU0;O94924;O95829;Q108M9;Q108N0;Q86TN7;

Protein name

Long-chain-fatty-acid--CoA ligase 6

Comment

FUNCTION:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.||CATALYTIC ACTIVITY:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.||COFACTOR:Magnesium.||SUBCELLULAR LOCATION:Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=8; Name=4; IsoId=Q9UKU0-4; Sequence=Displayed; Name=1; Synonyms=Long, v2; IsoId=Q9UKU0-1; Sequence=VSP 037819; Name=2; Synonyms=Short; IsoId=Q9UKU0-2; Sequence=VSP 021024, VSP 000241; Note=No e

Subcellular localization

Mitochondrion outer membrane;Single-pass type III membrane protein(By similarity).Peroxisome membrane;Single-pass type III membrane protein(By similarity).Microsome membrane;Single-pass type III membrane protein(By similarity).Endoplasmic reticulum membrane;Single-pass type III membrane protein(By similarity).

Gene name

acyl-CoA synthetase long-chain family member 6

Protein sequence

MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAIL AYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGP QLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPY QWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNR PEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADIS TVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALK ERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVC FTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQD DVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLS DDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLE FAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRM IVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTF TTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEI CVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPA GTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQI YVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLC TNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFS VQNGLLTPTLKAKRPELREYFKKQIEELYSISM

Database cross reference

RefSeq Protein accession:NP_001009185
RefSeq Protein gi:57165412

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;NAS:UniProtKB. GO:0005741;C:mitochondrial outer membrane;NAS:UniProtKB. GO:0005778;C:peroxisomal membrane;NAS:UniProtKB

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004467;F:long-chain fatty acid-CoA ligase activity;NAS:UniProtKB.

GO-P

GO:0006631;P:fatty acid metabolic process;IEA:UniProtKB-KW. GO:0035338;P:long-chain fatty-acyl-CoA biosynthetic process;TAS:Reactome. GO:0019432;P:triglyceride biosynthetic process;EXP:Reactome.