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Protein basic information

LiverAtlas Protein ID

HuLPr03765

Uniprot ID

ACSM3_HUMAN

Uniprot Acc

Q53FZ2;O60363;Q13732;Q15425;Q7KYM6;Q9BUA2;

Protein name

Acyl-coenzyme A synthetase ACSM3, mitochondrial

Comment

FUNCTION:Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity).||CATALYTIC ACTIVITY:ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.||COFACTOR:Magnesium (By similarity).||SUBCELLULAR LOCATION:Mitochondrion matrix (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53FZ2-1; Sequence=Displayed; Name=2; IsoId=Q53FZ2-2; Sequence=VSP 028395, VSP 028396;||SIMILARITY:Belongs to the ATP-dependent AMP-binding enzyme family.||CAUTION:It is uncertain whether Met-1 or Met-9 is the initiator.||SEQUENCE CAUTION:Sequence=AAC31667.1; Type=Erroneous initiation; Sequence=BAA03853.1; Type=Erroneous initiation; Sequence=CAA56369.1; Type=Erroneous initiation;

Subcellular localization

Mitochondrion matrix(By similarity).

Gene name

acyl-CoA synthetase medium-chain family member 3

Protein sequence

MLARVTRKMLRHAKCFQRLAIFGSVRALHKDNRTATPQNF SNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPS NPAFWWINRNGEEMRWSFEELGSLSRKFANILSEACSLQ RGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQK DILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLI VSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIFFT SGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWN TSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQ TLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCVSA GEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGM KIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVL PNRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDKDG YFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAV VSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVK KTTAPYKYPRKVEFIQELPKTISGKTKRNELRKKEWKTI

Database cross reference

RefSeq Protein accession:NP_005613
RefSeq Protein gi:42544132

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005759;C:mitochondrial matrix;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0047760;F:butyrate-CoA ligase activity;IEA:EC. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0008217;P:regulation of blood pressure;NAS:UniProtKB.