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Protein basic information

LiverAtlas Protein ID

HuLPr03767

Uniprot ID

ACSM5_HUMAN

Uniprot Acc

Q6NUN0;Q96AV1;Q96CX8;Q9NWV3;

Protein name

Acyl-coenzyme A synthetase ACSM5, mitochondrial

Comment

FUNCTION:Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity).||CATALYTIC ACTIVITY:ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.||COFACTOR:Magnesium or manganese (By similarity).||SUBCELLULAR LOCATION:Mitochondrion matrix (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUN0-1; Sequence=Displayed; Name=2; IsoId=Q6NUN0-2; Sequence=VSP 028398; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Detected in kidney and liver.||SIMILARITY:Belongs to the ATP-dependent AMP-binding enzyme family.||SEQUENCE CAUTION:Sequence=BAA91273.1; Type=Frameshift; Positions=560;

Subcellular localization

Mitochondrion matrix(By similarity).

Gene name

acyl-CoA synthetase medium-chain family member 5

Protein sequence

MRPWLRHLVLQALRNSRAFCGSHGKPAPLPVPQKIVATWE AISLGRQLVPEYFNFAHDVLDVWSRLEEAGHRPPNPAFW WVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRM MLVLPRLPEWWLVSVACMRTGTVMIPGVTQLTEKDLKYR LQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDSS RPGWLNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTG APKMVEHSQSSYGLGFVASGRRWVALTESDIFWNTTDTG WVKAAWTLFSAWPNGSCIFVHELPRVDAKVILNTLSKFP ITTLCCVPTIFRLLVQEDLTRYQFQSLRHCLTGGEALNP DVREKWKHQTGVELYEGYGQSETVVICANPKGMKIKSGS MGKASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFC FFNCYLDNPEKTAASEQGDFYITGDRARMDKDGYFWFMG RNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDP IRGEVVKAFIVLTPAYSSHDPEALTRELQEHVKRVTAPY KYPRKVAFVSELPKTVSGKIQRSKLRSQEWGK

Database cross reference

RefSeq Protein accession:NP_060358
RefSeq Protein gi:38505220

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005759;C:mitochondrial matrix;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0047760;F:butyrate-CoA ligase activity;IEA:EC. GO:0005525;F:GTP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0006631;P:fatty acid metabolic process;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03767

PHOSPHORYLATION

147

T

PhosphoSitePlus

1249852

LTP

HTP

N