HuLPr03768

Uniprot ID

ACSS3_HUMAN

Uniprot Acc

Q9H6R3;Q8NC66;

Protein name

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Comment

FUNCTION:Activates acetate so that it can be used for lipid synthesis or for energy generation (By similarity).||CATALYTIC ACTIVITY:ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.||SUBCELLULAR LOCATION:Mitochondrion (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H6R3-1; Sequence=Displayed; Name=2; IsoId=Q9H6R3-2; Sequence=VSP 031692;||SIMILARITY:Belongs to the ATP-dependent AMP-binding enzyme family.

Subcellular localization

Mitochondrion(Potential).

Gene name

acyl-CoA synthetase short-chain family member 3

Protein sequence

MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVP GPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGK AAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVD RHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLA GVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHS LIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYV PLVEEALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWD EEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPT GGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYIC YGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALF TAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDV ETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKT PPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPL PPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEG YLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAV VGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQ NIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPY KITSTIEDPSIFGHVEEMLKQA

Database cross reference

RefSeq Protein accession:NP_078836
RefSeq Protein gi:13375727

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005739;C:mitochondrion;IEA:UniProtKB-SubCell.

GO-F

GO:0003987;F:acetate-CoA ligase activity;IEA:EC. GO:0005524;F:ATP binding;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03768

ACETYLATION

524

K

PhosphoSitePlus

14320452

LTP

N

Propanoate_Metabolism