Protein basic information
| LiverAtlas Protein ID |
HuLPr03781 |
|
Uniprot ID |
|
|
Uniprot Acc |
O43707;O76048; |
|
Protein name |
Alpha-actinin-4 |
|
Comment |
FUNCTION:F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.||SUBUNIT:Homodimer; antiparallel (By similarity). Binds TRIM3 at the N-terminus (By similarity). Identified in a complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with BAIAP1 and PDLIM2.||INTERACTION:P35222:CTNNB1; NbExp=1; IntAct=EBI-351526, EBI |
|
Subcellular localization |
Nucleus.Cytoplasm. |
|
Gene name |
|
|
Related liver disease name |
|
|
Protein sequence
|
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDR DLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFR DGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDF IASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQD ISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGL AFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYL DIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKA ETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTI PWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQ LEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLE QAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR VEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSL THSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA MEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREA ILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEK VQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPW IQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPN LDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTT IARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDH GGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDP NHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDK NFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL |
|
Database cross reference |
RefSeq Protein accession:NP_004915
|
Liver relevance
|
HCC significant Proteins |
Yes/No |
Yes |
|
Quality score |
|
|
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005576;C:extracellular region;TAS:Reactome. GO:0005730;C:nucleolus;IDA:HPA. GO:0048471;C:perinuclear region of cytoplasm;IDA:UniProtKB. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome. GO:0043234;C:protein complex;IDA:UniProtKB. GO:0031143; |
|
GO-F |
GO:0051015;F:actin filament binding;IDA:UniProtKB. GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0005178;F:integrin binding;TAS:UniProtKB. GO:0001882;F:nucleoside binding;IDA:UniProtKB. GO:0042803;F:protein homodimerization activity;TAS:UniProtKB. |
|
GO-P |
GO:0030168;P:platelet activation;TAS:Reactome. GO:0002576;P:platelet de |